Impaired odor recognition memory in patients with hippocampal lesions | Zendy

Daniel A. Levy | Zendy; Ramona O. Hopkins | Zendy; Larry R. Squire | Zendy

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Impaired odor recognition memory in patients with hippocampal lesions

Author(s) -

Daniel A. Levy,

Ramona O. Hopkins,

Larry R. Squire

Publication year - 2004

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.82504

Subject(s) - hippocampal formation , recognition memory , neuroscience , hippocampus , impaired memory , psychology , odor , stimulus modality , memory impairment , olfactory memory , sensory system , cognition , central nervous system , olfactory bulb

In humans, impaired recognition memory following lesions thought to be limited to the hippocampal region has been demonstrated for a wide variety of tasks. However, the importance of the human hippocampus for olfactory recognition memory has scarcely been explored. We evaluated the ability of memory-impaired patients with damage thought to be limited to the hippocampal region to recognize a list of odors. The patients were significantly impaired after a retention delay of 1 h. Olfactory sensitivity was intact. This finding is in agreement with earlier reports that rats with hippocampal lesions exhibited memory impairment on an odor delayed nonmatching to sample task (after 30 min and 1 h) and that patients with damage thought to be limited to the hippocampal region were impaired on an odor span memory task. Olfactory recognition memory, similar to recognition memory in other sensory modalities, depends on the integrity of the hippocampal region.

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