Like Extinction, Latent Inhibition of Conditioned Fear in Mice Is Blocked by Systemic Inhibition of L-Type Voltage-Gated Calcium Channels | Zendy

Mark Barad | Zendy; Ashley M. Blouin | Zendy; Christopher K. Cain | Zendy

Open Access

Like Extinction, Latent Inhibition of Conditioned Fear in Mice Is Blocked by Systemic Inhibition of L-Type Voltage-Gated Calcium Channels

Author(s) -

Mark Barad,

Ashley M. Blouin,

Christopher K. Cain

Publication year - 2004

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.78304

Subject(s) - latent inhibition , extinction (optical mineralogy) , nifedipine , diltiazem , chemistry , psychology , voltage dependent calcium channel , neuroscience , calcium , conditioning , classical conditioning , statistics , mineralogy , mathematics , organic chemistry

Having recently shown that extinction of conditioned fear depends on L-type voltage-gated calcium channels (LVGCCs), we have been seeking other protocols that require this unusual induction mechanism. We tested latent inhibition (LI) of fear, because LI resembles extinction except that cue exposures precede, rather than follow, cue-shock pairing. Systemic injections of two LVGCC inhibitors, nifedipine and diltiazem, before pre-exposure blocked LI completely with no evidence of state-dependent learning. The results indicate that extinction and LI share a common molecular requirement and may support the notion that LI, like extinction, is a form of inhibitory learning.

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