Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice | Zendy

Jessica A. White | Zendy; Brandon C. McKinney | Zendy; Manorama C. John | Zendy; Patricia A. Powers | Zendy; Timothy J. Kamp | Zendy; Geoffrey G. Murphy | Zendy

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Conditional forebrain deletion of the L-type calcium channel Ca_V1.2 disrupts remote spatial memories in mice

Author(s) -

Jessica A. White,

Brandon C. McKinney,

Manorama C. John,

Patricia A. Powers,

Timothy J. Kamp,

Geoffrey G. Murphy

Publication year - 2008

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.773208

Subject(s) - forebrain , hippocampus , neuroscience , conditional gene knockout , chemistry , morris water navigation task , water maze , knockout mouse , calcium channel , calcium , psychology , central nervous system , biochemistry , receptor , phenotype , organic chemistry , gene

To determine whether L-type voltage-gated calcium channels (L-VGCCs) are required for remote memory consolidation, we generated conditional knockout mice in which the L-VGCC isoform Ca(V)1.2 was postnatally deleted in the hippocampus and cortex. In the Morris water maze, both Ca(V)1.2 conditional knockout mice (Ca(V)1.2(cKO)) and control littermates displayed a marked decrease in escape latencies and performed equally well on probe trials administered during training. In distinct contrast to their performance during training, Ca(V)1.2(cKO) mice exhibited significant impairments in spatial memory when examined 30 d after training, suggesting that Ca(V)1.2 plays a critical role in consolidation of remote spatial memories.

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