Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory | Zendy

Avis R. Brennan | Zendy; Beth Dolinsky | Zendy; Mai-Anh Vu | Zendy; Marion Stanley | Zendy; Mark F. Yeckel | Zendy; Amy F.T. Arnsten | Zendy

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Blockade of IP₃-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory

Author(s) -

Avis R. Brennan,

Beth Dolinsky,

Mai-Anh Vu,

Marion Stanley,

Mark F. Yeckel,

Amy F.T. Arnsten

Publication year - 2008

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.767408

Subject(s) - prefrontal cortex , neuroscience , working memory , blockade , psychology , chemistry , cognition , receptor , biochemistry

Planning and directing thought and behavior require the working memory (WM) functions of prefrontal cortex. WM is compromised by stress, which activates phosphatidylinositol (PI)-mediated IP 3 -PKC intracellular signaling. PKC overactivation impairs WM operations and in vitro studies indicate that IP 3 receptor (IP 3 R)-evoked calcium release results in SK channel-dependent hyperpolarization of prefrontal neurons. However, the effects of IP 3 R signaling on prefrontal function have not been investigated. The present findings demonstrate that blockade of IP 3 R or SK channels in the prefrontal cortex enhances WM performance in rats, suggesting that both arms of the PI cascade influence prefrontal cognitive function.

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