A Pharmacological Analysis of an Associative Learning Task: 5-HT1 to 5-HT7 Receptor Subtypes Function on a Pavlovian/Instrumental Autoshaped Memory | Zendy

Alfredo Meneses | Zendy

Open Access

A Pharmacological Analysis of an Associative Learning Task: 5-HT₁ to 5-HT₇ Receptor Subtypes Function on a Pavlovian/Instrumental Autoshaped Memory

Author(s) -

Alfredo Meneses

Publication year - 2003

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.60503

Subject(s) - associative learning , neuroscience , psychology , memory consolidation , 5 ht receptor , serotonin , cognition , receptor , biology , hippocampus , biochemistry

Recent studies using both invertebrates and mammals have revealed that endogenous serotonin (5-hydroxytryptamine [5-HT]) modulates plasticity processes, including learning and memory. However, little is currently known about the mechanisms, loci, or time window of the actions of 5-HT. The aim of this review is to discuss some recent results on the effects of systemic administration of selective agonists and antagonists of 5-HT on associative learning in a Pavlovian/instrumental autoshaping (P/I-A) task in rats. The results indicate that pharmacological manipulation of 5-HT1-7 receptors or 5-HT reuptake sites might modulate memory consolidation, which is consistent with the emerging notion that 5-HT plays a key role in memory formation.

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