Diencephalic Damage Decreases Hippocampal Acetylcholine Release During Spontaneous Alternation Testing | Zendy

Lisa M. Savage | Zendy; Qing Chang | Zendy; Paul E. Gold | Zendy

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Diencephalic Damage Decreases Hippocampal Acetylcholine Release During Spontaneous Alternation Testing

Author(s) -

Lisa M. Savage,

Qing Chang,

Paul E. Gold

Publication year - 2003

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.60003

Subject(s) - spontaneous alternation , acetylcholine , hippocampal formation , hippocampus , amnesia , neuroscience , psychology , chemistry , endocrinology , medicine , biology , psychiatry

A rodent model of diencephalic amnesia, pyrithiamine-induced thiaminedeficiency (PTD), was used to investigate diencephalic-hippocampalinteractions. Acetylcholine (ACh) release, a marker of memory-relatedactivation, was measured in the hippocampus of PTD-treated and control ratsprior to, during, and after spontaneous alternation test. During behavioraltesting, all animals displayed increases in ACh release. However, both thepercent increase of ACh release during spontaneous alternation testing and thealternation scores were higher in control rats relative to PTD-treated rats.Thus, when rats are tested on a task with demands dependent on thehippocampus, it appears that the hippocampus is not fully activated afterdiencephalic damage.

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