Perirhinal Cortex Lesions Impair Context Aversion Learning | Zendy

Dana Howse | Zendy; A. Squires | Zendy; Gerard M. Martin | Zendy; Darlene M. Skinner | Zendy

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Perirhinal Cortex Lesions Impair Context Aversion Learning

Author(s) -

Dana Howse,

A. Squires,

Gerard M. Martin,

Darlene M. Skinner

Publication year - 2003

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.57803

Subject(s) - perirhinal cortex , context (archaeology) , psychology , conditioning , saccharin , neuroscience , taste aversion , recognition memory , cognition , endocrinology , medicine , taste , biology , paleontology , statistics , mathematics

Rats with perirhinal cortex lesions were compared with sham controls on a conditional discrimination in which saccharin was paired with LiCl in context 1, but paired with saline in context 2. Perirhinal-lesioned rats were slightly slower to acquire the discrimination but reached control levels by the end of acquisition. Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2. Unlike sham rats, perirhinal rats failed to show an aversion to context 1 on a place choice test. These data provide neuroanatomical support for the postulated difference between Pavlovian conditioning and conditional learning.

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