D-Cycloserine enhances memory consolidation of hippocampus-dependent latent extinction | Zendy

Amanda Gabriele | Zendy; Mark G. Packard | Zendy

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D-Cycloserine enhances memory consolidation of hippocampus-dependent latent extinction

Author(s) -

Amanda Gabriele,

Mark G. Packard

Publication year - 2007

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.528007

Subject(s) - extinction (optical mineralogy) , nmda receptor , psychology , memory consolidation , hippocampus , neuroscience , cycloserine , agonist , latent inhibition , partial agonist , conditioning , developmental psychology , classical conditioning , anesthesia , chemistry , receptor , medicine , biochemistry , mineralogy , statistics , mathematics , antibiotics

Adult male Long-Evans rats were trained to run in a straight-alley maze for food reward and subsequently received hippocampus-dependent latent extinction training. Immediately following latent extinction, rats received peripheral injections of the NMDA receptor partial agonist D-cycloserine (DCS, 15 mg/kg), or saline. Twenty-four hours later, rats received four extinction "probe" trials. Relative to saline controls, latencies to reach the goal box on probe trials were significantly higher in rats that had received DCS. These findings indicate that memory consolidation underlying hippocampus-dependent latent extinction, a cognitive form of learning in which the previously rewarded response is not made during extinction training, can be enhanced by NMDA-receptor agonism.

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