LTP induction modifies functional relationship among hippocampal neurons | Zendy

Sung Hwan Yun | Zendy; Deok S. Lee | Zendy; Hyunjung Lee | Zendy; Eun Ha Baeg | Zendy; Yun B. Kim | Zendy; Min Whan Jung | Zendy

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LTP induction modifies functional relationship among hippocampal neurons

Author(s) -

Sung Hwan Yun,

Deok S. Lee,

Hyunjung Lee,

Eun Ha Baeg,

Yun B. Kim,

Min Whan Jung

Publication year - 2007

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.466307

Subject(s) - long term potentiation , neuroscience , hippocampal formation , ltp induction , functional connectivity , hippocampus , psychology , chemistry , biology , excitatory postsynaptic potential , inhibitory postsynaptic potential , receptor , biochemistry

To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered 'functional connectivity,' as defined by the degree of synchronous firing, among simultaneously recorded neurons in the CA3 region. Interestingly, functional connectivity changed bidirectionally so that the total sum of functional connectivity remained constant. These results demonstrate LTP-induced changes in neuronal functional connectivity and suggest the existence of a normalization mechanism for the total sum of functional connectivity.

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