English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Memories can have different strengths, largely dependent on the intensityof reinforcers encountered. The relationship between reinforcement and memorystrength is evident in asymptotic memory curves, with the level of theasymptote related to the intensity of the reinforcer. Although this is likelya fundamental property of memory formation, relatively little is known of howmemory strength is determined. Memory performance at different levels in Drosophila  can be measured in an operant heat-box conditioningparadigm. In this spatial learning paradigm, flies learn and remember to avoidone-half of a dark chamber associated with a temperature outside of thepreferred range. The reinforcement temperature has a strong effect on thelevel of learning in wild-type flies, with higher temperatures inducingstronger memories. Additionally, two mutations alter memory-acquisitioncurves, either changing acquisition rate or asymptotic memory level. The rutabaga  mutation, affecting a type-1 adenylyl cyclase, decreases theacquisition rate. In contrast, the  white  mutation, modifying an ABCtransporter, limits asymptotic memory. The  white  mutation does notnegatively affect classical olfactory conditioning but actually improvesperformance at low reinforcement levels. Thus, memory acquisition/memorystrength and classical olfactory/operant spatial memories can be geneticallydissociated. A conceptual model of operant conditioning and the levels atwhich  rutabaga  and  white  influence conditioning isproposed.

Genetic dissociation of acquisition and memory strength in the heat-box spatial learning paradigm in Drosophila