Synapse specificity of long-term potentiation breaks down with aging | Zendy

Laurence Ris | Zendy; Emile Godaux | Zendy

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Synapse specificity of long-term potentiation breaks down with aging

Author(s) -

Laurence Ris,

Emile Godaux

Publication year - 2007

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.451507

Subject(s) - long term potentiation , neuroscience , synapse , tetanic stimulation , neurotransmission , synaptic weight , chemistry , stimulation , psychology , computer science , artificial neural network , biochemistry , receptor , machine learning

Memory shows age-related decline. According to the current prevailing theoretical model, encoding of memories relies on modifications in the strength of the synapses connecting the different cells within a neuronal network. The selective increases in synaptic weight are thought to be biologically implemented by long-term potentiation (LTP). Here, we report that tetanic stimulation of afferent fibers in slices from 12-mo-old mice triggers an LTP not restricted to the activated synapses. This phenomenon, which can be anticipated to hinder memory encoding, is suppressed by blocking either L-type Ca(++) channels or Ca(++)-induced Ca(++) release, both well known to become disregulated with aging.

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