Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease | Zendy

Karen H. Ashe | Zendy

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Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease

Author(s) -

Karen H. Ashe

Publication year - 2001

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.43701

Subject(s) - genetically modified mouse , transgene , dementia , neuroscience , alzheimer's disease , amyloid precursor protein , disease , psychology , amyloid (mycology) , cognition , biology , pathology , medicine , genetics , gene

Recent advances in behavioral analyses of transgenic mouse models of Alzheimer's disease (AD) are discussed, and their impact on our understanding of the molecular basis of cognitive impairment in AD is considered. Studies of the relationship between memory and A Beta in transgenic mice expressing the amyloid precursor protein (APP) and its variants suggest that aging promotes the formation of soluble A Beta assemblies mediating negative effects on memory. A significant component of memory loss in APP transgenic mice is apparently caused by soluble A Beta assemblies, but whether and how much of the dementia within individuals afflicted with AD is caused by these A Beta species is unclear. Future studies in composite transgenic mice developing amyloid plaques, neurofibrillary tangles, and other AD pathology may allow for the determination of the relative contribution of A Beta and non-A Beta components to dementia.

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