Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm | Zendy

Seth D. Norrholm | Zendy; Tanja Jovanović | Zendy; Bram Vervliet | Zendy; Karyn M. Myers | Zendy; Michael Davis | Zendy; Barbara O. Rothbaum | Zendy; Erica Duncan | Zendy

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Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm

Author(s) -

Seth D. Norrholm,

Tanja Jovanović,

Bram Vervliet,

Karyn M. Myers,

Michael Davis,

Barbara O. Rothbaum,

Erica Duncan

Publication year - 2006

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.393906

Subject(s) - extinction (optical mineralogy) , psychology , fear potentiated startle , fear conditioning , moro reflex , cognitive psychology , fear processing in the brain , neuroscience , startle response , developmental psychology , amygdala , reflex , physics , optics

The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS- discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures.

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