Role of a Striatal Slowly Inactivating Potassium Current in Short-Term Facilitation of Corticostriatal Inputs: A Computer Simulation Study | Zendy

Séverine Mahon | Zendy; JeanMichel Deniau | Zendy; Stéphane Charpier | Zendy; Bruno Delord | Zendy

Open Access

Role of a Striatal Slowly Inactivating Potassium Current in Short-Term Facilitation of Corticostriatal Inputs: A Computer Simulation Study

Author(s) -

Séverine Mahon,

JeanMichel Deniau,

Stéphane Charpier,

Bruno Delord

Publication year - 2000

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.34800

Subject(s) - neuroscience , glutamatergic , depolarization , excitatory postsynaptic potential , facilitation , neural facilitation , chemistry , electrophysiology , neurotransmission , striatum , potassium channel , membrane potential , glutamate receptor , psychology , biophysics , biology , inhibitory postsynaptic potential , dopamine , receptor , biochemistry

Striatal output neurons (SONs) integrate glutamatergic synaptic inputs originating from the cerebral cortex. In vivo electrophysiological data have shown that a prior depolarization of SONs induced a short-term (≤1 sec) increase in their membrane excitability, which facilitated the ability of corticostriatal synaptic potentials to induce firing. Here we propose, using a computational model of SONs, that the use-dependent, short-term increase in the responsiveness of SONs mainly results from the slow kinetics of a voltage-dependent, slowly inactivating potassium A-current. This mechanism confers on SONs a form of intrinsic short-term memory that optimizes the synaptic input–output relationship as a function of their past activation.

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