A biochemist's view of long-term potentiation. | Zendy

Erik D. Roberson | Zendy; Joey D. English | Zendy; J. David Sweatt | Zendy

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A biochemist's view of long-term potentiation.

Author(s) -

Erik D. Roberson,

Joey D. English,

J. David Sweatt

Publication year - 1996

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.3.1.1

Subject(s) - long term potentiation , biochemist , neuroscience , hippocampus , psychology , perspective (graphical) , focus (optics) , term (time) , cognitive science , chemistry , computer science , biochemical engineering , artificial intelligence , biochemistry , engineering , receptor , physics , optics , quantum mechanics

This review surveys the molecular mechanisms of long-term potentiation (LTP) from the point of view of a biochemist. On the basis of available data, LTP in area CA1 of the hippocampus is divided into three phases--initial, early, and late--and the mechanisms contributing to the induction and expression of each phase are examined. We focus on evidence for the involvement of various second messengers and their effectors as well as the biochemical strategies employed in each phase to convert a transient signal into a lasting change in the neuron. We also consider, from a biochemical perspective, the implications of a multiphase model for LTP.

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