Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection | Zendy

Janice Chen | Zendy; Rosanna K. Olsen | Zendy; Alison R. Preston | Zendy; Gary H. Glover | Zendy; Anthony D. Wagner | Zendy

Open Access

Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection

Author(s) -

Janice Chen,

Rosanna K. Olsen,

Alison R. Preston,

Gary H. Glover,

Anthony D. Wagner

Publication year - 2011

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.2135211

Subject(s) - hippocampal formation , temporal lobe , psychology , associative property , neuroscience , cognitive psychology , cognition , mathematics , pure mathematics , epilepsy

Hippocampal subfields CA(3) and CA(1) are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes. Activity in the dentate gyrus/CA(2/3), CA(1), and other medial temporal lobe subregions tracked associative retrieval success, whereas activity in CA(1) and the perirhinal cortex tracked the presence of associative mismatches. These data support the hypothesis that CA(1) acts as a "comparator," detecting when memory for the past and sensory input in the present diverge.

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