Endurance factors improve hippocampal neurogenesis and spatial memory in mice | Zendy

Tali Kobilo | Zendy; Chunyan Yuan | Zendy; Henriette van Praag | Zendy

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Endurance factors improve hippocampal neurogenesis and spatial memory in mice

Author(s) -

Tali Kobilo,

Chunyan Yuan,

Henriette van Praag

Publication year - 2011

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.2001611

Subject(s) - neurogenesis , dentate gyrus , hippocampal formation , morris water navigation task , neuroscience , agonist , chemistry , hippocampus , water maze , endocrinology , receptor , psychology , medicine , biology

Physical activity improves learning and hippocampal neurogenesis. It is unknown whether compounds that increase endurance in muscle also enhance cognition. We investigated the effects of endurance factors, peroxisome proliferator-activated receptor δ agonist GW501516 and AICAR, activator of AMP-activated protein kinase on memory and neurogenesis. Mice were injected with GW for 7 d or AICAR for 7 or 14 d. Two weeks thereafter mice were tested in the Morris water maze. AICAR (7 d) and GW improved spatial memory. Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis. Thus, pharmacological activation of skeletal muscle may mediate cognitive effects.

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