Extinction of conditioned taste aversion depends on functional protein synthesis but not on NMDA receptor activation in the ventromedial prefrontal cortex | Zendy

Irit Akirav | Zendy; Vicktoria Khatsrinov | Zendy; RoseMarie Vouimba | Zendy; Maayan Merhav | Zendy; Guillaume Ferreira | Zendy; Kobi Rosenblum | Zendy; Mouna Maroun | Zendy

Open Access

Extinction of conditioned taste aversion depends on functional protein synthesis but not on NMDA receptor activation in the ventromedial prefrontal cortex

Author(s) -

Irit Akirav,

Vicktoria Khatsrinov,

RoseMarie Vouimba,

Maayan Merhav,

Guillaume Ferreira,

Kobi Rosenblum,

Mouna Maroun

Publication year - 2006

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.191706

Subject(s) - anisomycin , extinction (optical mineralogy) , ventromedial prefrontal cortex , taste aversion , nmda receptor , antagonist , neuroscience , psychology , prefrontal cortex , taste , receptor , chemistry , protein biosynthesis , biochemistry , cognition , mineralogy

We investigated the role of the ventromedial prefrontal cortex (vmPFC) in extinction of conditioned taste aversion (CTA) by microinfusing a protein synthesis inhibitor or N-methyl-d-asparate (NMDA) receptors antagonist into the vmPFC immediately following a non-reinforced extinction session. We found that the protein synthesis blocker anisomycin, but not the NMDA receptors antagonist D,L-2-amino-5-phosphonovaleric acid, impaired CTA extinction in the vmPFC. Anisomycin microinfusion into vmPFC had no effect on CTA acquisition and by itself did not induce CTA. These findings show the necessary role functional protein synthesis is playing in the vmPFC during the learning of CTA extinction.

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