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Combined activation of dopamine D1- and NMDA-glutamate receptors in the nucleus accumbens has been strongly implicated in instrumental learning, the process in which an individual learns that a specific action has a wanted outcome. To assess dopaminergic activity, we presented rats with two sessions (30 trials each) of a one-lever appetitive instrumental task and simultaneously measured dopamine efflux in the shell and core accumbens subareas using in vivo microdialysis. Dopamine efflux was increased during each session in all areas. The behavioral performance of the rats in the second session led us to divide them into a learning group (&gt;90% correct trials) and a non-learning group. In the first session, the rats of the learning group showed significantly higher increases. The difference was most pronounced in the shell. In the second session, the dopamine increase was similar in both groups, although the learning groups now pressed the lever about three times more often and consequently obtained more rewards. We conclude that task-related activation of dopamine efflux is different between learning and non-learning rats only during the learning phase. These results support the pharmacological evidence that dopamine is of particular importance during the instrumental learning process.

Individual differences in dopamine efflux in nucleus accumbens shell and core during instrumental learning