Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats | Zendy

Simon C. Spanswick | Zendy; Robert J. Sutherland | Zendy

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Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats

Author(s) -

Simon C. Spanswick,

Robert J. Sutherland

Publication year - 2010

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1746710

Subject(s) - dentate gyrus , corticosterone , adrenalectomy , hippocampal formation , novelty , neuroscience , bilateral adrenalectomy , psychology , association (psychology) , hippocampus , granule (geology) , glucocorticoid , endocrinology , context (archaeology) , medicine , biology , hormone , social psychology , paleontology , psychotherapist

Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat. Here, we administered replacement corticosterone to rats beginning 10 wk after ADX. We then tested them in three discrimination tasks based on object novelty, location, or object/context association. Only during testing of the object/context association did ADX rats demonstrate deficits. These findings add to a body of evidence that the hippocampus is necessary when contextual information is important. We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se.

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