Involvement of IP3 receptors in LTP and LTD induction in guinea pig hippocampal CA1 neurons | Zendy

Ahmed Mostafa Taufiq | Zendy; Satoshi Fujii | Zendy; Yoshihiko Yamazaki | Zendy; Hiroshi Sasaki | Zendy; Kenya Kaneko | Zendy; Jianmin Li | Zendy; Hiroshi Kato | Zendy; Katsuhiko Mikoshiba | Zendy

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Involvement of IP3 receptors in LTP and LTD induction in guinea pig hippocampal CA1 neurons

Author(s) -

Ahmed Mostafa Taufiq,

Satoshi Fujii,

Yoshihiko Yamazaki,

Hiroshi Sasaki,

Kenya Kaneko,

Jianmin Li,

Hiroshi Kato,

Katsuhiko Mikoshiba

Publication year - 2005

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.17405

Subject(s) - long term potentiation , tetanic stimulation , population spike , neuroscience , excitatory postsynaptic potential , long term depression , chemistry , metabotropic glutamate receptor , stimulation , ltp induction , metabotropic receptor , population , hippocampal formation , glutamate receptor , nmda receptor , antagonist , receptor , biology , ampa receptor , medicine , inhibitory postsynaptic potential , biochemistry , environmental health

The role of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) in long-termpotentiation (LTP) and long-term depression (LTD) was studied in CA1 neuronsin guinea pig hippocampal slices. In standard solution, short tetanicstimulation consisting of 15 pulses at 100 Hz induced LTP, while three shorttrains of low-frequency stimulation (LFS; 200 pulses at 1 Hz) at 18-minintervals or one long train of LFS (1000 pulses at 1 Hz) induced stable LTD inboth the slope of the field EPSP (S-EPSP) and the amplitude of the populationspike (A-PS). Bath application of 2-aminoethoxydiphenyl borate (2-APB), anIP3R antagonist, or of α-methyl-4-carboxyphenylglycine (MCPG), awide-spectrum metabotropic glutamate receptor antagonist, during weak tetanicstimulation significantly increased the magnitude of the LTP in both theS-EPSP and A-PS. Three short trains of LFS or one long train of LFS deliveredin the presence of 2-APB or MCPG did not induce LTD, but elicited LTP. Basedon these results, we conclude that, in hippocampal CA1 neurons, IP3Rs play animportant role in synaptic plasticity by attenuating LTP and facilitatingLTD.

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