Theta bursts in the olfactory nerve paired with β-adrenoceptor activation induce calcium elevation in mitral cells: A mechanism for odor preference learning in the neonate rat | Zendy

Qi Yuan | Zendy

Open Access

Theta bursts in the olfactory nerve paired with β-adrenoceptor activation induce calcium elevation in mitral cells: A mechanism for odor preference learning in the neonate rat

Author(s) -

Qi Yuan

Publication year - 2009

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1569309

Subject(s) - excitatory postsynaptic potential , long term potentiation , neuroscience , postsynaptic potential , inhibitory postsynaptic potential , odor , stimulation , olfactory system , olfaction , chemistry , medicine , psychology , receptor

Odor preference learning in the neonate rat follows pairing of odor input and noradrenergic activation of β-adrenoceptors. Odor learning is hypothesized to be supported by enhanced mitral cell activation. Here a mechanism for enhanced mitral cell signaling is described. Theta bursts in the olfactory nerve (ON) produce long-term potentiation (LTP) of glomerular excitatory postsynaptic potentials (EPSPs) and of excitatory postsynaptic currents (EPSCs) in the periglomerular (PG) and external tufted (ET) cells. Theta bursts paired with β-adrenoceptor activation significantly elevate mitral cell (MC) calcium. Juxtaglomerular inhibitory network depression by β-adrenoceptor activation appears to increase calcium in MCs in response to theta burst stimulation.

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