D-Cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion | Zendy

Irit Akirav | Zendy; Amir Segev | Zendy; Helen Motanis | Zendy; Mouna Maroun | Zendy

Open Access

D-Cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion

Author(s) -

Irit Akirav,

Amir Segev,

Helen Motanis,

Mouna Maroun

Publication year - 2009

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1565109

Subject(s) - extinction (optical mineralogy) , taste aversion , psychology , basolateral amygdala , fear conditioning , nmda receptor , neuroscience , amygdala , classical conditioning , taste , fear processing in the brain , developmental psychology , conditioning , receptor , chemistry , medicine , mineralogy , statistics , mathematics

We investigated whether the N -methyl- d -aspartate (NMDA) receptor partial agonist D-cycloserine (DCS, 20 μg/side) microinfused into the basolateral amygdala (BLA) would reverse stress-induced impairment of extinction in two aversive learning paradigms: contextual fear conditioning and conditioned taste aversion (CTA). We found that DCS in the BLA show differential involvement in the extinction of these two paradigms and in its modulation of stress-induced impairment of extinction. This may suggest that the dysfunctional extinction of fear and taste aversion following exposure to a stressful experience may be modulated by different mechanisms.

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