The hippocampus supports encoding of between-domain associations within working memory | Zendy

Carinne Piekema | Zendy; Roy P. C. Kessels | Zendy; Mark Rijpkema | Zendy; Guillén Fernández | Zendy

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The hippocampus supports encoding of between-domain associations within working memory

Author(s) -

Carinne Piekema,

Roy P. C. Kessels,

Mark Rijpkema,

Guillén Fernández

Publication year - 2009

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1283109

Subject(s) - hippocampus , functional magnetic resonance imaging , temporal lobe , neuroscience , psychology , encoding (memory) , stimulus (psychology) , associative property , episodic memory , cognitive psychology , cognition , mathematics , pure mathematics , epilepsy

It has been established that the medial temporal lobe, including the hippocampus, is crucial for associative memory. The aim of the current functional magnetic resonance imaging (fMRI) study was to investigate whether the hippocampus is differentially activated for associations between items processed in the same neocortical region (within-domain) as compared with associations between items processed in different neocortical regions (between-domain). Here, we show that the hippocampus is significantly more active for between-domain associations compared with within-domain associations. Thus, the hippocampus is important for associative encoding, and furthermore, shows greater activation when the stimuli to be associated come from different stimulus categories.

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