β-Adrenergic facilitation of synaptic plasticity in the rat basolateral amygdala in vitro is gradually reversed by corticosterone | Zendy

Zhenwei Pu | Zendy; Harm J. Krugers | Zendy; Marian Joëls | Zendy

Open Access

β-Adrenergic facilitation of synaptic plasticity in the rat basolateral amygdala in vitro is gradually reversed by corticosterone

Author(s) -

Zhenwei Pu,

Harm J. Krugers,

Marian Joëls

Publication year - 2009

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1272409

Subject(s) - basolateral amygdala , corticosterone , facilitation , amygdala , stimulation , neuroscience , synaptic plasticity , endocrinology , medicine , agonist , chemistry , neuroplasticity , psychology , receptor , hormone

The rat basolateral amygdala is important for emotional learning; this is modulated by noradrenaline and corticosterone. We report that the beta-adrenergic agonist isoproterenol markedly enhances synaptic plasticity induced in the basolateral amygdala by a weak stimulation paradigm but is ineffective with stronger protocols. Simultaneous application of corticosterone gradually reversed the facilitatory effect of isoproterenol. When corticosterone was briefly applied several hours prior to isoproterenol, facilitatory effects of the beta-agonist were entirely suppressed. This suggests that in the basolateral amygdala, beta-adrenergic influences promote synaptic plasticity; this is gradually normalized by corticosterone, preventing the network from overshooting.

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