Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A | Zendy

Nan Ma | Zendy; Ted Abel | Zendy; Pepe J. Hernandez | Zendy

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Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A

Author(s) -

Nan Ma,

Ted Abel,

Pepe J. Hernandez

Publication year - 2009

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1231009

Subject(s) - protein kinase a , memory consolidation , chemistry , long term memory , microbiology and biotechnology , kinase , neuroscience , hippocampus , psychology , biochemistry , biology , cognition

It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA, thus demonstrating the importance of Epac-mediated signaling in memory consolidation.

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