PKMζ inactivation induces spatial familiarity | Zendy

Diego Moncada | Zendy; Haydée Viola | Zendy

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PKMζ inactivation induces spatial familiarity

Author(s) -

Diego Moncada,

Haydée Viola

Publication year - 2008

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1139508

Subject(s) - hippocampal formation , context (archaeology) , spatial contextual awareness , spatial learning , open field , psychology , neuroscience , hippocampus , chemistry , cognitive psychology , biology , computer science , artificial intelligence , paleontology , psychiatry

Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place.

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