Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus | Zendy

Michael R. Foy | Zendy; Garnik Akopian | Zendy; Richard F. Thompson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus

Author(s) -

Michael R. Foy,

Garnik Akopian,

Richard F. Thompson

Publication year - 2008

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.1124708

Subject(s) - long term potentiation , synaptic plasticity , neurotransmission , hippocampus , synaptic fatigue , neuroscience , metaplasticity , synaptic augmentation , hippocampal formation , synaptic scaling , neuroplasticity , nonsynaptic plasticity , long term depression , extracellular , chemistry , biology , glutamate receptor , ampa receptor , biochemistry , receptor

Ovarian hormones influence memory formation by eliciting changes in neural activity. The effects of various concentrations of progesterone (P4) on synaptic transmission and plasticity associated with long-term potentiation (LTP) and long-term depression (LTD) were studied using in vitro hippocampal slices. Extracellular studies show that the highest concentration of P4 tested (10(-6) M) decreased the baseline synaptic transmission and magnitude of LTP, but did not affect LTD. Intracellular studies suggest the P4 effect to be mediated, at least in part, by GABA(A) activity. These results establish a general effect of P4 on synaptic transmission, multiple forms of synaptic plasticity, and a possible mechanism of P4 action in hippocampus.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research