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Recent evidence suggests that rats require an intact hippocampus in order to recognize familiar objects when they encounter them again in a different context. The two experiments reported here further examined how changes in context affect rats' performance on the novel-object preference (NOP) test of object-recognition memory, and how those effects interact with the effects of HPC damage. Rats with HPC lesions and control rats received NOP testing in either the same context in which they had previously encountered sample objects, or in a different but equally familiar context. In Experiment 1, the two contexts had very few overlapping cues within or outside the apparatus; thus, the differences between them were global. Consistent with previous results, control rats showed a novel-object preference in both the unchanged and (globally) changed contexts, whereas rats with HPC lesions displayed a preference only in the unchanged context. In Experiment 2, the context shift included only local features proximal to the test objects. The main results were the reverse of Experiment 1--rats with HPC lesions displayed a novel-object preference in both the unchanged and (locally) changed contexts, whereas control rats displayed a preference only in the unchanged context. The findings are consistent with the view that HPC damage does not cause a general inability to recognize objects, nor an inability to encode or store a representation of the context in which the objects are encountered. They suggest instead that HPC damage impairs the ability to remember specific locations of familiar objects within a particular context.

A limited role for the hippocampus in the modulation of novel-object preference by contextual cues