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Nr4a1  and  Nr4a2  are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either  Nr4a1  or  Nr4a2 , we found that  Nr4a2  is necessary for both long-term memory for object location and object recognition. In contrast,  Nr4a1  appears to be necessary only for object location. Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory.

Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory