The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex | Zendy

Sara Kuntz | Zendy; Burkhard Poeck | Zendy; Marla B. Sokolowski | Zendy; Roland Strauß | Zendy

Open Access

The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex

Author(s) -

Sara Kuntz,

Burkhard Poeck,

Marla B. Sokolowski,

Roland Strauß

Publication year - 2012

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.026369.112

Subject(s) - foraging , drosophila (subgenus) , neuroscience , drosophila melanogaster , orientation (vector space) , biology , mushroom bodies , gene , genetics , ecology , geometry , mathematics

Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila.

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