Medial prefrontal lesions in mice impair sustained attention but spare maintenance of information in working memory | Zendy

Julia B Kahn | Zendy; Ryan D. Ward | Zendy; Lora Kahn | Zendy; Nicole M. Rudy | Zendy; Eric R. Kandel | Zendy; Peter D. Balsam | Zendy; Eleanor H. Simpson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Medial prefrontal lesions in mice impair sustained attention but spare maintenance of information in working memory

Author(s) -

Julia B Kahn,

Ryan D. Ward,

Lora Kahn,

Nicole M. Rudy,

Eric R. Kandel,

Peter D. Balsam,

Eleanor H. Simpson

Publication year - 2012

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.026302.112

Subject(s) - working memory , cognition , psychology , task (project management) , neuroscience , cognitive psychology , continuous performance task , spare part , short term memory , construct (python library) , spatial memory , computer science , business , management , marketing , economics , programming language

Working memory and attention are complex cognitive functions that are disrupted in several neuropsychiatric disorders. Mouse models of such human diseases are commonly subjected to maze-based tests that can neither distinguish between these cognitive functions nor isolate specific aspects of either function. Here, we have adapted a simple visual discrimination task, and by varying only the timing of events within the same task construct, we are able to measure independently the behavioral response to increasing attentional demand and increasing length of time that information must be maintained in working memory. We determined that mPFC lesions in mice impair attention but not working memory maintenance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research