Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition | Zendy

Lourens J.P. kes | Zendy; Ilse I.G.M. van de Vondervoort | Zendy; Mark J.C. de Leeuw | Zendy; Linda Wijlaars | Zendy; Joseph H. R. Maes | Zendy; Judith R. Homberg | Zendy

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Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition

Author(s) -

Lourens J.P. kes,

Ilse I.G.M. van de Vondervoort,

Mark J.C. de Leeuw,

Linda Wijlaars,

Joseph H. R. Maes,

Judith R. Homberg

Publication year - 2012

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.025908.112

Subject(s) - cognitive flexibility , prefrontal cortex , serotonin transporter , latent inhibition , neuroscience , psychology , knockout mouse , flexibility (engineering) , orbitofrontal cortex , serotonin , cognition , chemistry , receptor , classical conditioning , biochemistry , statistics , mathematics , conditioning

Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT(-/-)) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT(-/-) rodents as well. Here we subjected 5-HTT(-/-) rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT(-/-) rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.

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