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The  Growth/differentiation factor  ( Gdf ) 5, 6, 7  genes form a closely related subgroup belonging to the TGF-β superfamily. In zebrafish, there are three genes that belong to the  Gdf5, 6, 7 subgroup that have been named  radar, dynamo , and contact . The genes  radar  and  dynamo  both encode proteins most similar to mouse GDF6. The orthologous identity of these genes on the basis of amino acid similarities has not been clear. We have identified  gdf7 , a fourth zebrafish gene belonging to the  Gdf5, 6, 7  subgroup. To assign correct orthologies and to investigate the evolutionary relationships of the human, mouse, and zebrafish  Gdf5, 6, 7 subgroup, we have compared genetic map positions of the zebrafish and mammalian genes. We have mapped zebrafish  gdf7  to linkage group (LG) 17,  contact  to LG9,  GDF6  to human chromosome (Hsa) 8 and  GDF7  to Hsa2p. The  radar  and dynamo  genes have been localized previously to LG16 and LG19, respectively. A comparison of syntenies shared among human, mouse, and zebrafish genomes indicates that  gdf7  is the ortholog of mammalian  GDF7/Gdf7 . LG16 shares syntenic relationships with mouse chromosome (Mmu) 4, including  Gdf6 . Portions of LG16 and LG19 appear to be duplicate chromosomes, thus suggesting that radar  and  dynamo  are both orthologs of  Gdf6 . Finally, the mapping data is consistent with  contact  being the zebrafish ortholog of mammalian  GDF5/Gdf5 .  [The sequence data described in this paper have been submitted to the GenBank data library under accession numbers  AF113022  and  AF113023 .]

genome research

Isolation of Zebrafish gdf7 and Comparative Genetic Mapping of Genes Belonging to the Growth/Differentiation Factor 5, 6, 7 Subgroup of the TGF-β Superfamily