A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence | Zendy

Liliana Florea | Zendy; George Hartzell | Zendy; Zheng Zhang | Zendy; Gerald M. Rubin | Zendy; Webb Miller | Zendy

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A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence

Author(s) -

Liliana Florea,

George Hartzell,

Zheng Zhang,

Gerald M. Rubin,

Webb Miller

Publication year - 1998

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.8.9.967

Subject(s) - biology , sequence (biology) , genetics , alignment free sequence analysis , genomic dna , computational biology , intron , dna sequencing , sequence logo , sequence analysis , sequence alignment , dna , gene , consensus sequence , base sequence , peptide sequence

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

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