A Physical Map of the Leishmania majorFriedlin Genome | Zendy

Alasdair Ivens | Zendy; Sharon Lewis | Zendy; Azadeh Bagherzadeh | Zendy; Linglan Zhang | Zendy; Ho Man Chan | Zendy; Deborah F. Smith | Zendy

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A Physical Map of the Leishmania majorFriedlin Genome

Author(s) -

Alasdair Ivens,

Sharon Lewis,

Azadeh Bagherzadeh,

Linglan Zhang,

Ho Man Chan,

Deborah F. Smith

Publication year - 1998

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.8.2.135

Subject(s) - contig , biology , cosmid , genome , computational biology , dna sequencing , genetics , sequence assembly , physical mapping , shuttle vector , dna , gene mapping , gene , vector (molecular biology) , chromosome , gene expression , transcriptome , recombinant dna

An extensive physical map of the Leishmania major Friedlin genome has been assembled by the combination of fingerprint analysis of a shuttle vector cosmid library and probe hybridization. The integrated data obtained for 9004 fingerprinted clones and 974 probes have placed 91.2% of the 33.58-Mb genome into contigs representing each of the 36 chromosomes. This first-generation map has already provided a suitable framework for both high-throughput DNA sequencing and functional studies of the L. major parasite.

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