Toward a Complete Human Genome Sequence | Zendy

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Toward a Complete Human Genome Sequence

Author(s) -

The Sanger Centre,

The Washington University Genome Sequencing Cente

Publication year - 1998

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.8.11.1097

Subject(s) - biology , shotgun sequencing , genome , genetics , sanger sequencing , sequence tagged site , human genome , sequence (biology) , whole genome sequencing , computational biology , genome project , reference genome , insert (composites) , contig , dna sequencing , gene , gene mapping , mechanical engineering , engineering , chromosome

We have begun a joint program as part of a coordinated international effort to determine a complete human genome sequence. Our strategy is to map large-insert bacterial clones and to sequence each clone by a random shotgun approach followed by directed finishing. As of September 1998, we have identified the map positions of bacterial clones covering approximately 860 Mb for sequencing and completed >98 Mb ( approximately 3.3%) of the human genome sequence. Our progress and sequencing data can be accessed via the World Wide Web (http://webace.sanger.ac.uk/HGP/ or http://genome.wustl.edu/gsc/).

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