A Linkage Map of the Rat Genome Derived from Three F2 Crosses | Zendy

Marie Thérèse Bihoreau | Zendy; Dominique Gauguier | Zendy; Norihiro Kato | Zendy; Gina Hyne | Zendy; Klaus Lindpaintner | Zendy; John P. Rapp | Zendy; Michael R. James | Zendy; G.M. Lathrop | Zendy

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A Linkage Map of the Rat Genome Derived from Three F₂ Crosses

Author(s) -

Marie Thérèse Bihoreau,

Dominique Gauguier,

Norihiro Kato,

Gina Hyne,

Klaus Lindpaintner,

John P. Rapp,

Michael R. James,

G.M. Lathrop

Publication year - 1997

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.7.5.434

Subject(s) - biology , genetics , microsatellite , genetic linkage , linkage (software) , genome , genetic linkage map , chromosome , phenotype , gene mapping , polymorphism (computer science) , gene , genotype , allele

We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F 2 populations from WKY × S ( n = 159), BN × S ( n = 91), and BN × GK ( n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

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