Coevolution of gene families in prokaryotes | Zendy

Otto X. Cordero | Zendy; ‎Berend Snel | Zendy; Paulien Hogeweg | Zendy

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Coevolution of gene families in prokaryotes

Author(s) -

Otto X. Cordero,

‎Berend Snel,

Paulien Hogeweg

Publication year - 2008

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6815508

Subject(s) - biology , coevolution , gene duplication , gene family , gene , evolutionary biology , functional divergence , function (biology) , genetics , phylogenetic tree , phylogenetics , concerted evolution , molecular evolution , genome

We study gene family coevolution on a tree of life based on a large-scale ancestral gene content reconstruction, which includes gene duplication and deletion events. The insights obtained from this study are threefold: (1) Global properties, such as the distribution of coevolution partners and the formation of disconnected clusters of coevolving families, can be an inevitable consequence of evolution along a tree. (2) Concerted family expansion (gene duplication) and contraction (gene deletion) reflect functional constraints and therefore lead to better function prediction. (3) "Long-range" coevolutionary relationships, caused mostly by large family expansions or contractions, reveal high-level evolutionary organization of cellular processes in prokaryotes.

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