A multidimensional analysis of genes mutated in breast and colorectal cancers | Zendy

Jimmy Lin | Zendy; Christine Gan | Zendy; Xiaosong Zhang | Zendy; Siân Jones | Zendy; Tobias Sjöblom | Zendy; Laura D. Wood | Zendy; D. Williams Parsons | Zendy; Nickolas Papadopoulos | Zendy; Kenneth W. Kinzler | Zendy; Bert Vogelstein | Zendy; Giovanni Parmigiani | Zendy; Victor E. Velculescu | Zendy

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A multidimensional analysis of genes mutated in breast and colorectal cancers

Author(s) -

Jimmy Lin,

Christine Gan,

Xiaosong Zhang,

Siân Jones,

Tobias Sjöblom,

Laura D. Wood,

D. Williams Parsons,

Nickolas Papadopoulos,

Kenneth W. Kinzler,

Bert Vogelstein,

Giovanni Parmigiani,

Victor E. Velculescu

Publication year - 2007

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6431107

Subject(s) - biology , gene , breast cancer , genetics , colorectal cancer , biological pathway , computational biology , somatic cell , bioinformatics , cancer , gene expression

A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention.

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