Identification of a novel paternally expressed transcript adjacent to snRPN in the Prader-Willi syndrome critical region. | Zendy

Yi Ning | Zendy; Anna V. Roschke | Zendy; Susan L. Christian | Zendy; J Lesser | Zendy; James S. Sutcliffe | Zendy; David H. Ledbetter | Zendy

Open Access

Identification of a novel paternally expressed transcript adjacent to snRPN in the Prader-Willi syndrome critical region.

Author(s) -

Yi Ning,

Anna V. Roschke,

Susan L. Christian,

J Lesser,

James S. Sutcliffe,

David H. Ledbetter

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.8.742

Subject(s) - biology , dinucleotide repeat , genetics , open reading frame , genomic imprinting , microbiology and biotechnology , gene , gene mapping , gene expression , peptide sequence , chromosome , dna methylation

Small nuclear ribonucleoprotein-associated polypeptide N (snRPN) and an anonymous transcript, PAR-5, are two of the paternally expressed transcripts mapped to the Prader-Willi syndrome critical region. Using long-range PCR, we have isolated the genomic interval between snRPN and PAR-5, identified a novel transcript in this region, and termed it PAR-SN. Northern analysis demonstrates that PAR-SN is expressed in brain, skeletal muscle, and heart. Like snRPN and PAR-5, PAR-SN is expressed exclusively from the paternal homolog in cultured lymphoblasts. Sequence analysis of the transcript revealed no significant open reading frame but did include a polymorphic dinucleotide repeat (CA)17.

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