Microsatellite hybrid capture technique for simultaneous isolation of various STR markers. | Zendy

Michal Procházka | Zendy

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Microsatellite hybrid capture technique for simultaneous isolation of various STR markers.

Author(s) -

Michal Procházka

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.7.646

Subject(s) - microsatellite , biology , genetics , computational biology , linkage (software) , genetic linkage , isolation (microbiology) , genetic marker , gene , bioinformatics , allele

The microsatellite hybrid capture technique was designed to enrich simultaneously for various microsatellite repeats from a genomic clone. It is illustrated in this report that different repeat motifs, including polymorphic ones, can be efficiently isolated in a single experiment. In principle, this technique can be applied to any type of genomic clones to facilitate the isolation of informative markers for fine mapping of subchromosomal regions of interest, and for linkage and association studies of candidate genes for which no polymorphic markers are available yet.

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