An integrated genetic map of the pearl locus of mouse chromosome 13. | Zendy

Albert Seymour | Zendy; B L Yanak | Zendy; Edward P. O’Brien | Zendy; Michael E. Rusiniak | Zendy; E. K. Novák | Zendy; Lawrence H. Pinto | Zendy; Richard T. Swank | Zendy; Michael B. Gorin | Zendy

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An integrated genetic map of the pearl locus of mouse chromosome 13.

Author(s) -

Albert Seymour,

B L Yanak,

Edward P. O’Brien,

Michael E. Rusiniak,

E. K. Novák,

Lawrence H. Pinto,

Richard T. Swank,

Michael B. Gorin

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.6.538

Subject(s) - biology , genetics , locus (genetics) , gene mapping , radiation hybrid mapping , gene , versican , chromosome , microbiology and biotechnology , extracellular matrix , proteoglycan

We have used a Mus domesticus/spretus congenic animal and two interspecific backcross panels to map genetically 30 sequence-tagged sites (STSs) and 13 genes to the vicinity of the pearl locus on mouse chromosome 13. The STSs defining the mapped region are from D13Mit9 to D13Mit37, spanning 10.6 cM. Genes mapped to this region include Versican (Cspg2), GTPase activating protein (Rasa), dihydrofolate reductase (Dhfr), arylsulfatase (As-1), thrombin receptor (Cf2r), hexosaminidase b(Hexb), 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), microtubule associated protein 5/1b (Mtap5), phosphodiesterase (Pde), phosphatidylinositol 3' kinase (Pik3rl), rat integrin a1-subunit (Itga1), collagen receptor a2-subunit (Itga2), and 5-hydroxytryptamine 1a receptor (Htr1a). This high resolution genetic map of the pearl region of chromosome 13 establishes the order of multiple markers, including genes whose human homologs are located within a limited region of human chromosome 5, with respect to the phenotypic anchor marker pearl.

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