A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. | Zendy

M. Ali AnsariLari | Zendy; Donna M. Muzny | Zendy; Jing Lü | Zendy; Fei Lü | Zendy; Caroline E. Lilley | Zendy; S Spanos | Zendy; Tracy M. Malley | Zendy; Richard A. Gibbs | Zendy

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A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

Author(s) -

M. Ali AnsariLari,

Donna M. Muzny,

Jing Lü,

Fei Lü,

Caroline E. Lilley,

S Spanos,

Tracy M. Malley,

Richard A. Gibbs

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.4.314

Subject(s) - biology , triosephosphate isomerase , genetics , gene , intron , shotgun sequencing , exon , sequence analysis , complementary dna , gene cluster , genomic dna , dna sequencing , microbiology and biotechnology

The genomic sequence of the human CD4 gene and its neighboring region, located at chromosome 12p13, was generated using the large-scale shotgun sequencing strategy. A total of 117 kb of genomic sequence and approximately 11 kb of cDNA sequence were obtained. Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new genes with unknown functions were identified. Using a battery of strategies, the exon/intron boundaries, splice variants, and tissue expression patterns of the genes were determined. Various computer software was utilized for analyses of the DNA and amino acid sequences. The results of the analyses and sequence-based strategies for gene identification are discussed.

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