Mapping the human Y chromosome by fingerprinting cosmid clones. | Zendy

Kay Taylor | Zendy; Nick Hornigold | Zendy; David J. Conway | Zendy; D. Clive Williams | Zendy; Z. Ulinowski | Zendy; M Agochiya | Zendy; Paolo Fattorini | Zendy; Peter J. de Jong | Zendy; Peter Little | Zendy; Jonathan Wolfe | Zendy

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Mapping the human Y chromosome by fingerprinting cosmid clones.

Author(s) -

Kay Taylor,

Nick Hornigold,

David J. Conway,

D. Clive Williams,

Z. Ulinowski,

M Agochiya,

Paolo Fattorini,

Peter J. de Jong,

Peter Little,

Jonathan Wolfe

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.4.235

Subject(s) - cosmid , contig , biology , genetics , chromosome , genomic library , sequence tagged site , computational biology , gene mapping , gene , genome , base sequence

We have used Y-specific cosmid clones in a random fingerprinting approach to build contigs on the human Y chromosome. Clones derived from two libraries have been analyzed. The construction of one library is described here, the second was the Y chromosome-specific library LLOYNCO3 "M" (Lawrence Livermore National Laboratory). To date, we have fingerprinted 4430 cosmids: 377 contigs have been constructed containing from 2 to 39 clones. Along with the singletons, we estimate that we have covered 72.5% of the euchomatic portion of the Y chromosome with fingerprinted clones. Sequence tagged sites are being used to anchor cosmids and contigs onto the YAC framework.

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