An integrated YAC map of the human X chromosome. | Zendy

Hugues Roest Crollius | Zendy; M. T. Ross | Zendy; Andrey Grigoriev | Zendy; Catherine J. Knights | Zendy; Eric Holloway | Zendy; J Misfud | Zendy; Ke Li | Zendy; M Playford | Zendy; Simon G. Gregory | Zendy; Sean Humphray | Zendy; Alison J. Coffey | Zendy; C.G. See | Zendy; Sharon Marsh | Zendy; R Vatcheva | Zendy; Johan Kumlien | Zendy; Tullio Labella | Zendy; Veronica Lam | Zendy; Kim Hyeung Rak | Zendy; Kathleen Todd | Zendy; Richard Mott | Zendy; D Graeser | Zendy; Gudrun Rappold | Zendy; G. Zehetner | Zendy; Annemarie Poustka | Zendy; Hans Lehrach | Zendy

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An integrated YAC map of the human X chromosome.

Author(s) -

Hugues Roest Crollius,

M. T. Ross,

Andrey Grigoriev,

Catherine J. Knights,

Eric Holloway,

J Misfud,

Ke Li,

M Playford,

Simon G. Gregory,

Sean Humphray,

Alison J. Coffey,

C.G. See,

Sharon Marsh,

R Vatcheva,

Johan Kumlien,

Tullio Labella,

Veronica Lam,

Kim Hyeung Rak,

Kathleen Todd,

Richard Mott,

D Graeser,

Gudrun Rappold,

G. Zehetner,

Annemarie Poustka,

Hans Lehrach

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.10.943

Subject(s) - contig , biology , genetics , gene mapping , chromosome , genome , gene , computational biology

The human X chromosome is associated with a large number of disease phenotypes, principally because of its unique mode of inheritance that tends to reveal all recessive disorders in males. With the longer term goal of identifying and characterizing most of these genes, we have adopted a chromosome-wide strategy to establish a YAC contig map. We have performed > 3250 inter Alu-PCR product hybridizations to identify overlaps between YAC clones. Positional information associated with many of these YAC clones has been derived from our Reference Library Database and a variety of other public sources. We have constructed a YAC contig map of the X chromosome covering 125 Mb of DNA in 25 contigs and containing 906 YAC clones. These contigs have been verified extensively by FISH and by gel and hybridization fingerprinting techniques. This independently derived map exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps.

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