Karyotype distributions in a stochastic model of reciprocal translocation. | Zendy

David Sankoff | Zendy; Vincent Ferretti | Zendy

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Karyotype distributions in a stochastic model of reciprocal translocation.

Author(s) -

David Sankoff,

Vincent Ferretti

Publication year - 1996

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.6.1.1

Subject(s) - chromosomal translocation , biology , karyotype , chromosome , reciprocal , distribution (mathematics) , genetics , evolutionary biology , statistical physics , mathematics , gene , physics , mathematical analysis , linguistics , philosophy

A random process of reciprocal translocation for a fixed number k of chromosomes (or arms) will have an equilibrium distribution of chromosome lengths. In this paper we calculate this distribution, by analytical means for k = 2 and partially for k = 3, and simulate the means of the marginal distributions for higher k. We compare this with a random (i.e., ahistorical) distribution of genomic DNA among k chromosomes and to a selection of karyotypes of real organisms. The results motivate a revised model where translocations giving rise to undersize chromosomes are disadvantaged.

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