Regions of high differentiation—Worth a check | Zendy

Bettina Harr | Zendy

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Regions of high differentiation—Worth a check

Author(s) -

Bettina Harr

Publication year - 2006

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.5787706

Subject(s) - biology , genetics , subspecies , snp , genome , evolutionary biology , single nucleotide polymorphism , computational biology , gene , genotype , zoology

B. Boursot and K. Belkhir in this issue of Genome Research point to an ascertainment bias in my use of SNPs to identify regions of high differentiation between a pair of house mouse subspecies. Here, I discuss additional points to consider and argue that the ultimate test for such regions should be an independent confirmation using unrelated samples. I provide evidence that regions of high differentiation as identified from laboratory strains and potentially biased SNP markers can be confirmed and therefore are worth a deeper investigation.

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