A radiation hybrid map of 40 loci for the distal long arm of human chromosome 8. | Zendy

Tracey Lewis | Zendy; Lawrence M. Nelson | Zendy; Ken Ward | Zendy; Robin J. Leach | Zendy

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A radiation hybrid map of 40 loci for the distal long arm of human chromosome 8.

Author(s) -

Tracey Lewis,

Lawrence M. Nelson,

Ken Ward,

Robin J. Leach

Publication year - 1995

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.5.4.334

Subject(s) - biology , genetics , chinese hamster ovary cell , chromosome , radiation hybrid mapping , gene mapping , genetic marker , hybrid , gene , cell culture , botany

We generated a panel of 97 radiation hybrids from the cell line GM10156B, which contains only human chromosome 8 in a Chinese hamster ovary cell line background. Statistical analysis of the cosegregation of markers in the 97 radiation hybrids was used to construct a physical map delineating the order and intermarker distance of 40 8q24 loci. Twenty-one loci were ordered with maximum likelihood ratios greater than 1000:1. A high level of consistency was seen between our RH map and the published genetic map, suggesting that our panel will be a valuable resource for the rapid mapping of markers derived from human chromosome 8.

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