Emerging technologies in DNA sequencing | Zendy

Michael L. Metzker | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Emerging technologies in DNA sequencing

Author(s) -

Michael L. Metzker

Publication year - 2005

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.3770505

Subject(s) - sanger sequencing , biology , dna sequencing , computational biology , genomics , emerging technologies , personal genomics , genome , genetics , dna , gene , computer science , artificial intelligence

Demand for DNA sequence information has never been greater, yet current Sanger technology is too costly, time consuming, and labor intensive to meet this ongoing demand. Applications span numerous research interests, including sequence variation studies, comparative genomics and evolution, forensics, and diagnostic and applied therapeutics. Several emerging technologies show promise of delivering next-generation solutions for fast and affordable genome sequencing. In this review article, the DNA polymerase-dependent strategies of Sanger sequencing, single nucleotide addition, and cyclic reversible termination are discussed to highlight recent advances and potential challenges these technologies face in their development for ultrafast DNA sequencing.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research